Technology

Porous materials with large surface area have many positive effects in applications such as drug delivery, catalysis and production of nanoparticles. Mesoporous silica with pores that are 2-50 nm in size and have a specific surface area of 500-1000 m2/g have since its first discovery in the early 90’s been of great interest to the research community. The large surface area makes the material useful in catalysis and gas storage since many reactions can occur in a small amount of material. The narrow pore size distribution makes them suitable to use as sieves that can separate molecules of different size or as molds for growing nanoparticles, yielding particles of uniform and controlled size which can be very difficult to do in such solution.

Electron micrographs of separated mesoporous silica particles.

The material is synthesized in a sol-gel process where the surfactants and silica precursor are mixed with other additives in order to alter the pore size and particle morphology. We are focusing on synthesizing SBA-15 like materials with cylindrical pores arranged in a hexagonal structure. It has been shown that our materials consisting of separate particles with unusually short and wide pores are beneficial in applications such as drug delivery systems [1], and enzyme immobilization [2].

  1. Targeted delivery of a new anticancer compound Anisomelic acid using chitosan-coated porous silica nanorods for an enhanced apoptotic effect in vitro
    R. Senthilkumar, D. Şen Karaman, P. Paul, E.M. Björk, M. Odén, J.E. Eriksson, and J.M. Rosenholm
    Accepted for publication in Biomaterial Science DOI: 10.1039/c4bm00278d
  1. Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization
    D. Sen Karaman, D. Desai, R. Senthilkumar, E.M. Johansson, N. Råtts, M. Odén, J.E. Eriksson, C. Sahlgren, D.M. Toivola and J.M. Rosenholm
    Nanoscale Research Letters 7 (2012) 358
  1. Immobilization of lipase from Mucor miehei and Rhizopus oryzae into mesoporous silica – The effect of varied particle size and morphology
    H. Gustafsson, E.M. Johansson, A. Barrabino, M. Odén and K. Holmberg
    Colloids and Surfaces B: Biointerfaces 100 (2012) 22